ACDC Seminar by Kyle Wedgwood on May 21

On May 21 at 16:00, Kyle Wedgwood will give an Amsterdam Dynamics Seminar. We will go for drinks at Bar Boele after the talk.

The talk will take place in the Maryam seminar room (9A-46).

Title:  A Closed-loop Framework for Model Discrimination and Parametrisation
Using Optimal Control

Abstract: The ability to accurately predict the response of an observed
system to a known input is a fruitful first step to accurately control
the system’s dynamics. Despite the recent advances in fully data-driven
algorithms, the most interpretable way to reach this goal is through
mechanistic mathematical modeling. It is not always possible or
straightforward to develop a description of a system of interest from
first principles. Often one has to rely on empirical, effective models,
with the drawback of having many potential candidates competing at
explaining some phenomenon. In such a case, there is often no simple way
to choose which one provides the best description as these models might
often give similar predictions. In this work, we leverage optimal
control and propose a closed-loop iterative method to choose among a set
of candidate models the one that most accurately predict an observed
system. We assume that one has the ability to apply control to an input
of the observed system and access to measurements of its response. Our
approach is then to identify the input control that maximally
discriminates the response of the candidate models, allowing us to
determine which model is best by comparing such responses with the
observed data. We first demonstrate our proposed iterative scheme in
numerical simulations before applying it during an electrophysiology
experiment, successfully discriminating between three different models
for photocurrents produced via opsin dynamics. We anticipate that, given
its general nature, our scheme is well suited for many other biological
and non-biological applications

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